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mavacamten will decrease the level or effect of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may possibly reduce systemic exposures of ethinyl estradiol and progestin, which can bring about contraceptive failure or an inc